getwater.tech getwater .tech
← Back to Contaminants
Placeholder hero image (16:9)

ADONA

4,8-dioxa-3H-perfluorononanoic acid

2,2,3-trifluoro-3-[1,1,2,2,3,3-hexafluoro-3-(trifluoromethoxy)propoxy]propanoic acid

Also known as ADONA ADONA
Adona4,8-Dioxa-3H-perfluorononanoic acid2,2,3-Trifluoro-3-(1,1,2,2,3,3-hexafluoro-3-(trifluoromethoxy)propoxy)propanoic acid2J86RN9BGDC7H2F12O43H-Perfluoro-4,8-dioxanonanoic acidFT177428HOOC-CF2-CHF-O-(CF2)3-O-CF3

A perfluoroether carboxylic acid developed by 3M/Dyneon as a PFOA replacement for fluoropolymer manufacturing. Persistent in the environment; detected at low ppt levels in U.S. drinking water under EPA's UCMR 5 monitoring program.

Group
PFAS
Regulatory status
UCMR
Unregulated Contaminant Monitoring Rule
Top removal tech
Activated carbon

Primary concern: Immune and liver toxicity

Affected organ systems

Liver Immune Developmental Endocrine Affecting the body's hormone system — thyroid, adrenal, reproductive, or metabolic hormones. Thyroid

Health effects

Immunotoxin Suppresses or alters the immune system. Can increase risk of infection or reduce vaccine effectiveness. Endocrine disruptor Mimics or blocks the body's hormones (estrogen, thyroid, testosterone). Can affect development, reproduction, and metabolism at very low doses. Developmental toxin Causes harm during development before birth or in early childhood — birth defects, low birth weight, delayed growth, or learning problems later in life. Hepatotoxin Damages the liver. Effects range from elevated liver enzymes on a blood test to fatty liver disease and, with prolonged exposure, liver cancer.

Exposure routes

Drinking water Dietary Occupational

Vulnerable populations

Pregnant Infants Children

Overview

4,8-Dioxa-3H-perfluorononanoic acid (ADONA), commonly sold under the trade name ADONA as its ammonium salt, is a short-to-medium-chain perfluoroether carboxylic acid. It was introduced by 3M and its German subsidiary Dyneon around 2008 as a 'next-generation' processing aid for fluoropolymer manufacturing (PTFE, PFA, FEP), intended as a replacement for PFOA after the EPA's 2010/2015 PFOA Stewardship Program. Like the closely related Chemours product GenX (HFPO-DA), ADONA was marketed as having a shorter half-life in humans than legacy long-chain PFAS — but it shares the same extreme environmental persistence and has now been detected in 55 U.S. public water systems serving roughly 712,000 people under EPA's UCMR 5 monitoring program.

Pollution sources

Industry Manufacturing

Sources

ADONA enters drinking water primarily through industrial discharges from fluoropolymer manufacturing plants. The principal known source is Dyneon's Gendorf facility in Bavaria, Germany, where ADONA has been used since 2008; in the United States, smaller-scale use and atmospheric long-range transport account for most documented occurrence. UCMR 5 detections so far cluster in New York, California, Texas, Alabama, and the Northeast, with the highest reported level (18.8 ppt) at a small mobile-home park in Selkirk, NY. As with other perfluoroether acids, ADONA is highly mobile in groundwater, resists degradation indefinitely, and does not partition strongly into soil or sediment.

Health risks

ADONA has not been formally classified as a carcinogen by IARC or NTP, and its toxicological dataset is smaller than that of PFOA or PFOS. Animal studies have nonetheless reported hepatotoxicity, thyroid effects, and developmental impacts at oral doses in the same range as other PFAS of concern. Manufacturer-funded biomonitoring of workers at Dyneon's Gendorf plant reported a human serum elimination half-life on the order of weeks-to-months — much shorter than PFOA (~2.4 years) — but independent verification is limited, and the underlying environmental persistence is unchanged. ADONA is monitored under UCMR 5 but is not currently subject to a federal MCL.

Effective treatments

Activated carbon Granular or block carbon that traps organic contaminants as water flows through. The most common point-of-use filter media — handles chlorine taste, VOCs, pesticides, and many PFAS. Reverse osmosis A semipermeable membrane that pushes water through under pressure, leaving most dissolved contaminants behind. Removes a very broad range — PFAS, lead, arsenic, nitrate, salts — at the cost of slower flow and some wastewater. Ion exchange Resin beads that swap unwanted ions (lead, calcium, certain PFAS, perchlorate) for harmless ones like sodium. Common in water softeners and PFAS treatment columns.

Does not remove

UV Ultraviolet light that disrupts the DNA of bacteria, viruses, and protozoa as water flows past the lamp. Disinfects but doesn't remove chemicals or particles. Chlorination Adds chlorine or hypochlorite to kill bacteria and viruses. The most common disinfection method in US water systems; leaves a residual that keeps water protected through the distribution pipes. Boil Kills bacteria, viruses, and protozoa after a one-minute rolling boil. Does NOT remove chemicals like lead, nitrate, or PFAS — boiling actually concentrates them as water evaporates.

NSF certifications

NSF/ANSI 53 Health-related contaminants NSF/ANSI 58 Reverse osmosis systems

Water treatment

ADONA is removed effectively by granular activated carbon (GAC), anion exchange resin, and high-pressure membranes including reverse osmosis and nanofiltration. Because ADONA is a shorter-chain perfluoroether acid, it adsorbs less strongly to GAC than long-chain PFAS such as PFOA — GAC breakthrough occurs sooner, so treatment plants must monitor and replace media more frequently. Conventional treatment processes — coagulation, sand filtration, disinfection, UV, and ozonation — do not remove it. Boiling concentrates rather than removes it. NSF/ANSI 53 and NSF P473 certify point-of-use filters for PFAS reduction; NSF/ANSI 58 covers RO systems.

Gallery

Related contaminants

Chemistry + classification data sourced from public databases (PubChem, EPA CompTox, IARC monographs); 3D molecular models from 3d.nih.gov where available.